Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
Author:
Affiliation:
1. Molecular Modeling and Drug Discovery Lab, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
2. Analytical Chemistry and in Vivo Pharmacology, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
Funder
Associazione Italiana per la Ricerca sul Cancro
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01760
Reference61 articles.
1. Drugging Topoisomerases: Lessons and Challenges
2. The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
3. DNA topology and topoisomerases
4. Multifaceted properties of 1,4-dimethylcarbazoles: Focus on trimethoxybenzamide and trimethoxyphenylurea derivatives as novel human topoisomerase II inhibitors
5. Progress and challenges towards targeted delivery of cancer therapeutics
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