Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency
Author:
Affiliation:
1. School of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
2. Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 162, Copenhagen DK-2100, Denmark
Funder
Ministry of Higher Education and Scientific Research-Kurdistan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00519
Reference22 articles.
1. Structure and synthesis of a potent glutamate receptor antagonist in wasp venom.
2. δ-philanthotoxin, a semi-irreversible blocker of ion-channels
3. An analysis of philanthotoxin block for recombinant rat GluR6(Q) glutamate receptor channels
4. Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors
5. Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor
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