Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability-Reference-Cited by-同舟云学术

Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability

Published:2019-06-13 Issue:13 Volume:62 Page:6276-6286
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Stone Tracy A.¹,Cole Gregory B.²,Ravamehr-Lake Dorna²,Nguyen Huong Q.²,Khan Farheen²,Sharpe Simon²,Deber Charles M.²^ORCID

Affiliation:

1. Department of Biochemistry, University of Toronto, Toronto, M5S 1A8 Ontario, Canada

2. Division of Molecular Medicine, Research Institute, Hospital for Sick Children, Toronto M5G 0A4 Ontario, Canada

Funder

Cystic Fibrosis Foundation

Natural Sciences and Engineering Research Council of Canada

Hospital for Sick Children

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00657

Reference50 articles.

1. Antibacterial drug discovery in the resistance era

2. Antimicrobial Peptides: An Emerging Category of Therapeutic Agents

3. Amphipathic, α-helical antimicrobial peptides

4. Antimicrobial peptides of multicellular organisms

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