Dopamine D4 Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy-Reference-Cited by-同舟云学术

Dopamine D4 Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy

Published:2019-03-18 Issue:7 Volume:62 Page:3722-3740
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Keck Thomas M.¹²^ORCID,Free R. Benjamin³,Day Marilyn M.³,Brown Sonvia L.⁴,Maddaluna Michele S.⁴,Fountain Griffin¹,Cooper Charles¹,Fallon Brooke¹,Holmes Matthew¹,Stang Christopher T.³,Burkhardt Russell⁵,Bonifazi Alessandro⁵,Ellenberger Michael P.⁵,Newman Amy H.⁵^ORCID,Sibley David R.³,Wu Chun¹,Boateng Comfort A.⁴^ORCID

Affiliation:

1. Department of Chemistry & Biochemistry, Department of Molecular & Cellular Biosciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States

2. Cooper Medical School of Rowan University, 401 Broadway, Camden, New Jersey 08103, United States

3. Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, United States

4. Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States

5. Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States

Funder

National Institute on Drug Abuse

National Institute of Neurological Disorders and Stroke

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00231

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2. Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain