Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis-Reference-Cited by-同舟云学术

Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis

Published:2019-05-11 Issue:11 Volume:62 Page:5470-5500
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cioffi Christopher L.¹^ORCID,Racz Boglarka²,Varadi Andras²,Freeman Emily E.,Conlon Michael P.,Chen Ping,Zhu Lei,Kitchen Douglas B.,Barnes Keith D.,Martin William H.³,Pearson Paul G.⁴,Johnson Graham⁵,Blaner William S.⁶,Petrukhin Konstantin²

Affiliation:

1. Departments of Basic and Clinical Sciences and Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, 106 New Scotland Avenue, Albany, New York 12208, United States

2. Department of Ophthalmology, Columbia University Medical Center, New York, New York 10032, United States

3. WHM Consulting LLC, 111 Sterling City Road, Lyme, Connecticut 06371, United States

4. Pearson Pharma Partners, 31194 La Baya Drive, Westlake Village, California 91361, United States

5. NuPharmAdvise LLC, 3 Lakeside Drive, Sanbornton, New Hampshire 03269, United States

6. Department of Medicine, Columbia University Medical Center, New York, New York 10032, United States

Funder

National Institute of Neurological Disorders and Stroke

National Eye Institute

National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Health and Human Services

NIH Blueprint for Neuroscience Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00352

Reference50 articles.

1. Lipocalins in drug discovery: From natural ligand-binding proteins to ‘anticalinsʼ

2. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

3. Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness

4. Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6

5. Liver Retinol Transporter and Receptor for Serum Retinol-binding Protein (RBP4)

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