Combined Directed Ortho Metalation/Cross-Coupling Strategies: Synthesis of the Tetracyclic A/B/C/D Ring Core of the Antitumor Agent Camptothecin
Author:
Affiliation:
1. The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Waterloo, Waterloo, ON, Canada N2L 3G1
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo049890h
Reference47 articles.
1. Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2
2. Biogenetically patterned synthesis of camptothecin and 20-deoxycamptothecin
3. Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogs of camptothecin
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