Monitoring and Control of a Continuous Grignard Reaction for the Synthesis of an Active Pharmaceutical Ingredient Intermediate Using Inline NIR spectroscopy-Reference-Cited by-同舟云学术

Monitoring and Control of a Continuous Grignard Reaction for the Synthesis of an Active Pharmaceutical Ingredient Intermediate Using Inline NIR spectroscopy

Published:2012-02-14 Issue:5 Volume:16 Page:901-914
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Cervera-Padrell Albert E.¹,Nielsen Jesper P.²,Jønch Pedersen Michael¹,Müller Christensen Kim¹,Mortensen Asmus R.¹,Skovby Tommy²,Dam-Johansen Kim¹,Kiil Søren¹,Gernaey Krist V.¹

Affiliation:

1. Department of Chemical and Biochemical Engineering, Technical University of Denmark (DTU), Building 229, DK-2800 Kgs. Lyngby, Denmark

2. Chemical Production Development, H. Lundbeck A/S, Oddenvej 182, DK-4500 Nykoebing Sj., Denmark

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op2002563

Reference39 articles.

1. New Developments in Chemical Engineering for the Production of Drug Substances

2. Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers