Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase from Leishmania donovani chagasi, the Protozoan Parasite Responsible for Leishmaniasis

Author:

Syrjänen Leo12,Vermelho Alane Beatriz3,de Almeida Rodrigues Igor3,Corte-Real Suzana4,Salonen Terhi12,Pan Peiwen12,Vullo Daniela5,Parkkila Seppo126,Capasso Clemente7,Supuran Claudiu T.58

Affiliation:

1. Institute of Biomedical Technology and BioMediTech, University of Tampere, 33520 Tampere, Finland

2. School of Medicine, University of Tampere and Tampere University Hospital, 33014 Tampere, Finland

3. Biotechnology Center−BIOINOVAR: Bioenergy, Biocatalysis and Bioproducts, Federal University of Rio de Janeiro, 21941-901 Rio de Janeiro, Brazil

4. Laboratory of Structural Biology, Oswaldo Cruz Institute (OCI) Platform, Manguinhos, 21040-360, Rio de Janeiro, RJ Brazil

5. Laboratorio di Chimica Bioinorganica, Dipartimento di Chimica, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy

6. Fimlab Laboratories Ltd, 33101 Tampere, Finland

7. Istituto di Biochimica delle Proteine−CNR, Via Pietro Castellino 111, 80131 Napoli, Italy

8. Neurofarba Dipartimento, Sezione di Scienza Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via Ugo Sciff 6, 50019 Sesto Fiorentino, Firenze, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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