Separation and Characterization of an IgG2 Antibody Containing a Cyclic Imide in CDR1 of Light Chain by Hydrophobic Interaction Chromatography and Mass Spectrometry
Author:
Affiliation:
1. Process and Analytical Sciences, Amgen Inc., Seattle, Washington 98119
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ac702245c
Reference37 articles.
1. Preparative Purification of a Recombinant Protein by Hydrophobic Interaction Chromatography: Modulation of Selectivity by the Use of Chaotropic Additives
2. Application of hydrophobic interaction displacement chromatography for an industrial protein purification
3. Development and Scale up of Preparative HIC for the Purification of a Recombinant Therapeutic Protein
4. Development of an analytical reversed-phase high-performance liquid chromatography–electrospray ionization mass spectrometry method for characterization of recombinant antibodies
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