Inhibition of Human Neutrophil Elastase. 4. Design, Synthesis, X-ray Crystallographic Analysis, and Structure−Activity Relationships for a Series of P2-Modified, Orally Active Peptidyl Pentafluoroethyl Ketones-Reference-Cited by-同舟云学术

Inhibition of Human Neutrophil Elastase. 4. Design, Synthesis, X-ray Crystallographic Analysis, and Structure−Activity Relationships for a Series of P2-Modified, Orally Active Peptidyl Pentafluoroethyl Ketones

Published:1998-06-03 Issue:14 Volume:41 Page:2461-2480
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cregge Robert J.¹,Durham Sherrie L.¹,Farr Robert A.¹,Gallion Steven L.¹,Hare C. Michelle¹,Hoffman Robert V.¹,Janusz Michael J.¹,Kim Hwa-Ok¹,Koehl Jack R.¹,Mehdi Shujaath¹,Metz William A.¹,Peet Norton P.¹,Pelton John T.¹,Schreuder Herman A.¹,Sunder Shyam¹,Tardif Chantal¹

Affiliation:

1. Hoechst Marion Roussel Inc., 2110 East Galbraith Road, Cincinnati, Ohio 45215

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970812e

Reference63 articles.

1. Alpha1-Antitrypsin Deficiency and Emphysema Caused by Homozygous Inheritance of Non-Expressing Alpha1-Antitrypsin Genes

2. The role of elastases in the development of emphysema

3. Biochemical links between cigarette smoking and pulmonary emphysema

4. Depletion of Cartilage Matrix by a Neutral Protease Fraction of Human Leukocyte Lysosomes

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