Complete Stereochemistry and Preliminary Structure–Activity Relationship of Rakicidin A, a Hypoxia-Selective Cytotoxin from Micromonospora sp.
Author:
Affiliation:
1. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan
2. Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan
Funder
Research Supporters Association
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/np500276c
Reference22 articles.
1. Hypoxia in cancer: significance and impact on clinical outcome
2. Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment
3. Tumor hypoxia as a driving force in genetic instability
4. Targeting hypoxia in cancer therapy
5. Rakicidin A: A Hypoxia-Selective Cytotoxin
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