1. Department of Surgery, University of Hong Kong, Pokfulam, Hong Kong, China, Department of Surgery and Department of Pharmacology, National University Health System, National University of Singapore, 117597 Singapore, Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China, and Interdisciplinary Molecular Medicine, The Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom