Nonpeptide Bradykinin B2 Receptor Antagonists: Conversion of Rodent-Selective Bradyzide Analogues into Potent, Orally-Active Human Bradykinin B2 Receptor Antagonists-Reference-Cited by-同舟云学术

Nonpeptide Bradykinin B2 Receptor Antagonists: Conversion of Rodent-Selective Bradyzide Analogues into Potent, Orally-Active Human Bradykinin B2 Receptor Antagonists

Published:2002-04-24 Issue:11 Volume:45 Page:2160-2172
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dziadulewicz Edward K.¹,Ritchie Timothy J.¹,Hallett Allan¹,Snell Christopher R.¹,Davies John W.¹,Wrigglesworth Roger¹,Dunstan Andrew R.¹,Bloomfield Graham C.¹,Drake Gillian S.¹,McIntyre Peter¹,Brown Michael C.¹,Burgess Gillian M.¹,Lee Wai¹,Davis Clare¹,Yaqoob Mohammed¹,Phagoo Steve B.¹,Phillips Elsa¹,Perkins Martin N.¹,Campbell Elizabeth A.¹,Davis Andrew J.¹,Rang Humphrey P.¹

Affiliation:

1. Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BS, England

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0111088

Reference57 articles.

1. A portion of this work has been presented previously. Dziadulewicz, E.; Ritchie, T.; Hallett, A.; Snell, C.; Ko, S.; Davies, J.; Wrigglesworth, R.; Burgess, G.; Brown, M.; McIntyre, P.; Perkins, M.; Campbell, E.; Urban, L.; Rang, H.; Dunstan, A.; Bloomfield, G.; Drake, G.; Hughes, G.; Lee, W.; Davis, C.; Yaqoob, M.; Phagoo, S.; Phillips, E.; Davis, A. Synthesis and Biological Evaluation of 1-(2-Nitrophenyl)thiosemicarbazide Derivatives as Novel Bradykinin B2Receptor Antagonists. Presented at the 2000 International Chemical Congress of Pacific Basin Societies, Honolulu, HI, Dec. 14−19, 2000; MEDI 33.

2. Effect of bradykinin antagonists on bradykinin-induced plasma extravasation, venoconstriction, prostaglandin E2 release, nociceptor stimulation and contraction of the iris sphincter muscle in the rabbit

3. Neuron atrophy during aging: programmed or sporadic?

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