Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines

Author:

Highland Jaclyn N.12,Morris Patrick J.3ORCID,Konrath Kylie M.4,Riggs Lace M.15,Hagen Natalie R.4,Zanos Panos167,Powels Chris F.1,Moaddel Ruin8,Thomas Craig J.3ORCID,Wang Amy Q.4,Gould Todd D.16910ORCID

Affiliation:

1. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States

2. Program in Toxicology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States

3. Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Rockville, Maryland 20850, United States

4. Therapeutics for Rare and Neglected Diseases, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States

5. Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States

6. Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States

7. Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States

8. Biomedical Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States

9. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States

10. Veterans Affairs Maryland Health Care System, Baltimore, Maryland 21201, United States

Funder

National Institute of Mental Health

US Veterans Affairs

US Veterans Administration

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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