Small-Molecule Targeted Aβ42 Aggregate Degradation: Negatively Charged Small Molecules Are More Promising than the Neutral Ones-Reference-Cited by-同舟云学术

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Small-Molecule Targeted Aβ42 Aggregate Degradation: Negatively Charged Small Molecules Are More Promising than the Neutral Ones

Published:2021-03-09 Issue:7 Volume:12 Page:1197-1209
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Mei Jinfei¹,Yang Huijuan¹,Sun Bo¹,Liu Chengqiang¹,Ai Hongqi¹^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P. R. China

Funder

Shandong Provincial Natural Science Foundation, China

Shandong Provincial Key Research & Development Plan (Public Welfare Special Project) of China

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.1c00047

Reference77 articles.

1. Folding proteins in fatal ways

2. Amyloid plaque core protein in Alzheimer disease and Down syndrome.

3. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

4. C-Terminal Turn Stability Determines Assembly Differences between Aβ40 and Aβ42

5. Studies on the in Vitro Assembly of Aβ 1–40: Implications for the Search for Aβ Fibril Formation Inhibitors

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1. Synthesis and bio-activities of bifunctional tetrahydrosalen Cu (II) chelators with potential efficacy in Alzheimer's disease therapy;Journal of Inorganic Biochemistry;2024-10

2. Origin of stronger binding of ionic pair (IP) inhibitor to Aβ42 than the equimolar neutral counterparts: synergy mechanism of IP in disrupting Aβ42 protofibril and inhibiting Aβ42 aggregation under two pH conditions;Physical Chemistry Chemical Physics;2023

3. Identification and characterization of the conformation and size of amyloid-β (42) oligomers targeting the receptor LilrB2;Physical Chemistry Chemical Physics;2023

4. Molecular engineering and activity improvement of acetylcholinesterase inhibitors: Insights from 3D-QSAR, docking, and molecular dynamics simulation studies;Journal of Molecular Graphics and Modelling;2022-11

5. Inhibitory Mechanisms of Three Modified Small Molecules on the Misfolding of Cu ²⁺ ‐Aβ42 Complex in Different pH Conditions: Insights from MD/QM Studies;ChemistrySelect;2022-10-04

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