1. Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States
2. Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States
3. Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States
4. Department of Pharmacodynamics, University of Florida, Gainesville, Florida 032610, United States
5. Department of Anesthesiology, Rutgers New Jersey Medical School, Newark, New Jersey 07103, United States
6. Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, United States