New Pyrimidine and Pyridine Derivatives as Multitarget Cholinesterase Inhibitors: Design, Synthesis, and In Vitro and In Cellulo Evaluation

Author:

Bortolami Martina1ORCID,Pandolfi Fabiana1,Tudino Valeria2,Messore Antonella2,Madia Valentina Noemi2,De Vita Daniela3,Di Santo Roberto4ORCID,Costi Roberta4ORCID,Romeo Isabella56,Alcaro Stefano56,Colone Marisa7,Stringaro Annarita7,Espargaró Alba8,Sabatè Raimon8ORCID,Scipione Luigi2ORCID

Affiliation:

1. Department of Scienze di Base e Applicate per l’Ingegneria, Sapienza University of Rome, via Castro Laurenziano 7, I-00161 Rome, Italy

2. Department of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy

3. Department of Environmental Biology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy

4. Istituto Pasteur, Fondazione Cenci Bolognetti, Department of Chemistry and Technology of Drug, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy

5. Net4Science s.r.l., Campus universitario ″S. Venuta″, Viale Europa, 88100 Catanzaro, Italy

6. Dipartimento di Scienze della Salute, Università ″Magna Græcia″ di Catanzaro, Viale Europa, 88100 Catanzaro, Italy

7. National Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Viale Regina Elena, 00161 Rome, Italy

8. Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Avda. Joan XXIII, 27-31 Barcelona, Catalonia, Spain

Funder

Istituto Superiore di Sanit??

Ministero dell???Istruzione, dell???Universit?? e della Ricerca

Sapienza Universit?? di Roma

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Reference52 articles.

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