Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments-Reference-Cited by-同舟云学术

Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments

Published:2022-01-20 Issue:3 Volume:13 Page:390-405
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Xia Chuang¹,He Jia-Peng¹,Feng Kai-Wen¹,Liu Lu¹,Zheng Lei¹,Wang Hai-Tao¹^ORCID,Xu Jiang-Ping¹^ORCID,Zhou Zhong-Zhen¹²^ORCID

Affiliation:

1. Innovation Program of Drug Research on Neurological and Metabolic Diseases, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

2. Pharmacy Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China

Funder

Guangzhou Science and Technology Program key projects

National Natural Science Foundation of China

Guangdong Basic and Applied Basic Research Foundation

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.1c00762

Reference29 articles.

1. Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery

2. Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

3. Understanding the structure–activity and structure–selectivity correlation of cyclic guanine derivatives as phosphodiesterase-5 inhibitors by molecular docking, CoMFA and CoMSIA analyses

4. Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain

5. Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches

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