“Photo-Rimonabant”: Synthesis and Biological Evaluation of Novel Photoswitchable Molecules Derived from Rimonabant Lead to a Highly Selective and Nanomolar “Cis-On” CB1R Antagonist-Reference-Cited by-同舟云学术

“Photo-Rimonabant”: Synthesis and Biological Evaluation of Novel Photoswitchable Molecules Derived from Rimonabant Lead to a Highly Selective and Nanomolar “Cis-On” CB1R Antagonist

Published:2021-04-15 Issue:9 Volume:12 Page:1632-1647
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Rodríguez-Soacha Diego A.¹,Fender Julia²,Ramírez Yesid A.¹³,Collado Juan Antonio⁴,Muñoz Eduardo⁴,Maitra Rangan⁵^ORCID,Sotriffer Christoph¹,Lorenz Kristina²⁶,Decker Michael¹^ORCID

Affiliation:

1. Pharmazeutische und Medizinische Chemie, Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany

2. Institut für Pharmakologie und Toxikologie, Julius-Maximilians-Universität Würzburg, Versbacher Straße 9, D-97078 Würzburg, Germany

3. Departmento de Ciencias Farmacéuticas, Facultad de Ciencias Naturales, Universidad Icesi, 760031 Cali, Valle del Cauca, Colombia

4. Instituto Maimónides de Investigación Biomédica de Córdoba, Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Hospital Universitario Reina Sofía, Avda Menendez Pidal s/n, 14004 Córdoba, Spain

5. Discovery Science and Technology, RTI International, 3040 Cornwallis Road, Research Triangle Park, North Carolina 27709-2194, United States

6. Leibniz-Institut für Analytische Wissenschaften—ISAS e.V., Bunsen-Kirchhoff-Straße 11, 44139 Dortmund, Germany

Funder

Deutscher Akademischer Austauschdienst

Elitenetzwerk Bayern

National Institute of Diabetes and Digestive and Kidney Diseases

Deutsche Forschungsgemeinschaft

European Cooperation in Science and Technology

National Institute on Alcohol Abuse and Alcoholism

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)