Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice

Author:

Parvin Farjana1,Haglund Samuel1,Wegenast-Braun Bettina23,Jucker Mathias23,Saito Takashi45,Saido Takaomi C.4,Nilsson K. Peter R.1ORCID,Nilsson Per6,Nyström Sofie1ORCID,Hammarström Per1ORCID

Affiliation:

1. Department of Physics, Chemistry and Biology (IFM), Linköping University, 58183 Linköping, Sweden

2. German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, 72076 Tübingen, Germany

3. Hertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany

4. Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako 351-0198, Saitama, Japan

5. Department of Neurocognitive Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Aichi, Japan

6. Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, 17177 Solna, Sweden

Funder

Vetenskapsr?det

Bertil H?llstens Forskningsstiftelse

Torsten S?derbergs Stiftelse

Hj?rnfonden

Familjen Erling-Perssons Stiftelse

Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse

Alzheimer Sverige

Publisher

American Chemical Society (ACS)

Reference57 articles.

1. The neuropathological diagnosis of Alzheimer’s disease

2. Alzheimers Research UK. Alzheimer′s Disease Symptoms. 2023. https://www.alzheimersresearchuk.org/dementia-information/types-of-dementia/alzheimers-disease/symptoms/ (accessed 2023 4 July).

3. The Amyloid-β Pathway in Alzheimer’s Disease

4. Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

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