Novel HDAC6 Inhibitors Increase Tubulin Acetylation and Rescue Axonal Transport of Mitochondria in a Model of Charcot–Marie

Novel HDAC6 Inhibitors Increase Tubulin Acetylation and Rescue Axonal Transport of Mitochondria in a Model of Charcot–Marie–Tooth Type 2F

Published:2019-12-17 Issue:3 Volume:11 Page:258-267
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Adalbert Robert¹²^ORCID,Kaieda Akira³^ORCID,Antoniou Christina¹,Loreto Andrea¹,Yang Xiuna¹,Gilley Jonathan¹,Hoshino Takashi³,Uga Keiko³,Makhija Mahindra T.⁴,Coleman Michael P.¹⁵

Affiliation:

1. John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site Robinson Way, Cambridge CB2 0PY, United Kingdom

2. Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Szeged, Szeged H-6724, Hungary

3. Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

4. Takeda Development Centre Europe Ltd., 61 Aldwych, London WC2B 4AE, United Kingdom

5. Babraham Institute, Babraham, Cambridge CB22 3AT, United Kingdom

Funder

Takeda Development Centre Europe Ltd.

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.9b00338

Reference60 articles.

1. A Kinesin Heavy Chain (KIF5A) Mutation in Hereditary Spastic Paraplegia (SPG10)

2. Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2

3. Hot-spot KIF5A mutations cause familial ALS

4. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

5. KIF5Amutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction

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