Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies-Reference-Cited by-同舟云学术

Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies

Published:2019-12-18 Issue:3 Volume:11 Page:268-290
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Journigan V. Blair¹²^ORCID,Feng Zhiwei³⁴⁵,Rahman Saifur⁶,Wang Yuanqiang³⁴⁵,Amin A. R. M. Ruhul¹²,Heffner Colleen E.¹,Bachtel Nicholas¹,Wang Siyi³⁴⁵,Gonzalez-Rodriguez Sara⁷,Fernández-Carvajal Asia⁷,Fernández-Ballester Gregorio⁷,Hilton Jacob K.⁸⁹¹⁰,Van Horn Wade D.⁸⁹¹⁰^ORCID,Ferrer-Montiel Antonio⁷,Xie Xiang-Qun³⁴⁵^ORCID,Rahman Taufiq⁶^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, West Virginia 25755, United States

2. Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia 25755, United States

3. Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States

4. NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States

5. Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States

6. Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1TN, United Kingdom

7. IDiBE: Instituto de Investigación, Desarrollo e innovación en Biotecnología sanitaria de Elche, Universitas Miguel Hernández, 03202 Elche, Spain

8. The School of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, United States

9. the Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona 85281, United States

10. The Magnetic Resonance Research Center, Arizona State University, Tempe, Arizona 85287, United States

Funder

Ministerio de Economía y Competitividad

National Institute on Drug Abuse

National Institute of General Medical Sciences

School of Pharmacy, Marshall University

Cambridge Trust

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.9b00404

Reference118 articles.

1. Inhibition of TRPM8 Channels Reduces Pain in the Cold Pressor Test in Humans

2. Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c-fibers and colocalization with trk receptors

3. Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain

4. Identification of a cold receptor reveals a general role for TRP channels in thermosensation

5. Ligand stoichiometry of the cold- and menthol-activated channel TRPM8

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