Discovery of Arginine Ethyl Ester as Polyglutamine Aggregation Inhibitor: Conformational Transitioning of Huntingtin N-Terminus Augments Aggregation Suppression-Reference-Cited by-同舟云学术

Discovery of Arginine Ethyl Ester as Polyglutamine Aggregation Inhibitor: Conformational Transitioning of Huntingtin N-Terminus Augments Aggregation Suppression

Published:2019-08-28 Issue:9 Volume:10 Page:3969-3985
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Singh Virender¹²^ORCID,Patel Kinjal A.³,Sharma Raj Kumar⁴,Patil Pratik R.¹,Joshi Abhayraj S.¹^ORCID,Parihar Rashmi¹,Athilingam Thamarailingam¹,Sinha Neeraj⁴^ORCID,Ganesh Subramaniam¹,Sinha Pradip¹,Roy Ipsita³^ORCID,Thakur Ashwani Kumar¹^ORCID

Affiliation:

1. Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India

2. Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, United States

3. Department of Biotechnology, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, India

4. Centre of Biomedical Research, SGPGIMS Campus, Raibarelly Road, Lucknow, Uttar Pradesh 226014, India

Funder

Indian Council of Medical Research

Indian Institute of Technology Kanpur

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.9b00167

Reference70 articles.

1. Huntington's disease: a clinical review

2. Huntingtin and the molecular pathogenesis of Huntington's disease

3. Huntingtin aggregation and toxicity in Huntington's disease

4. Huntington's disease: An update of therapeutic strategies

5. Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

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