Translation of HDAC6 PET Imaging Using [18F]EKZ-001–cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates

Author:

Celen Sofie1ORCID,Rokka Johanna2,Gilbert Tonya M.3ORCID,Koole Michel4,Vermeulen Isabeau1,Serdons Kim5,Schroeder Frederick A.3ORCID,Wagner Florence F.6,Bleeser Tom7ORCID,Hightower Baileigh G.2,Hu Jiyun8,Rahal Dania8,Beyzavi Hudson8ORCID,Vanduffel Wim29,Van Laere Koen45,Kranz Janice E.3ORCID,Hooker Jacob M.2ORCID,Bormans Guy1,Cawthorne Christopher J.4ORCID

Affiliation:

1. Laboratory for Radiopharmaceutical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium

2. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, United States

3. Eikonizo Therapeutics, Inc., Cambridge, Massachusetts 02139, United States

4. Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, 3000 Leuven, Belgium

5. Division of Nuclear Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium

6. Center for the Development of Therapeutics, Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, United States

7. Anesthesiology and Algology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium

8. Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas 72701, United States

9. Laboratory for Neuro- and Psychophysiology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium

Funder

Emil Aaltosen S??ti?

National Institute of Neurological Disorders and Stroke

Alzheimer's Drug Discovery Foundation

University of Arkansas

Sigrid Jus?liuksen S??ti?

KU Leuven

Maud Kuistilan Muistos??ti?

Fonds Wetenschappelijk Onderzoek

National Institute of General Medical Sciences

Eikonizo Therapeutics, Inc.

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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