Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells-Reference-Cited by-同舟云学术

Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells

Published:2020-06-22 Issue:15 Volume:11 Page:2286-2295
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Lo Chih Hung¹,Pandey Nitin K.²,Lim Colin Kin-Wye¹,Ding Zhipeng¹,Tao Meixin²,Thomas David D.³⁴,Langen Ralf²,Sachs Jonathan N.¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States

3. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States

4. Photonic Pharma LLC, Minneapolis, Minnesota 55410, United States

Funder

University of Minnesota

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.0c00226

Reference50 articles.

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

2. Huntington disease: natural history, biomarkers and prospects for therapeutics

3. Polyglutamine Repeats in Neurodegenerative Diseases

4. Multiple clinical features of Huntington’s disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration

5. CAG repeat number governs the development rate of pathology in Huntington's disease

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