Synthesis and Preclinical Evaluation of 6-[18F]Fluorine-α-methyl-l-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake-Reference-Cited by-同舟云学术

Synthesis and Preclinical Evaluation of 6-[18F]Fluorine-α-methyl-l-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake

Published:2020-04-28 Issue:12 Volume:11 Page:1756-1761
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Krasikova Raisa¹²,Kondrashov Mikhail¹^ORCID,Avagliano Camilla¹,Petukhov Mikhail³⁴,Vazquez-Romero Ana¹,Revunov Evgeny¹,Johnström Peter¹⁵,Tari Lenke¹,Tóth Miklós¹,Häggkvist Jenny¹,Erhardt Sophie⁶,Cervenka Simon¹,Schou Magnus¹⁵^ORCID

Affiliation:

1. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Health Care Services, Region Stockholm, SE-171 76, Stockholm, Sweden

2. N.P. Bechtereva Institute of Human Brain, Russian Academy of Science, 9, Pavlov str., 197376 St. Petersburg, Russia

3. Petersburg Nuclear Physics Institute named after B.P. Konstantinov, NRC “Kurchatov Institute”, 188300 Gatchina, Russia

4. Russian Scientific Center of Radiology and Surgical Technologies named after A.M. Granov, 197758 St. Petersburg, Russia

5. PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, S-171 76 Stockholm, Sweden

6. Department of Physiology & Pharmacology, Karolinska Institutet, SE- 171 77 Stockholm, Sweden

Funder

AstraZeneca

Vetenskapsr?det

Knut och Alice Wallenbergs Stiftelse

Russian Foundation for Basic Research

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.0c00135

Reference27 articles.

1. Quantitative aspects of tryptophan metabolism in humans and other species: a review

2. α[C-11]Methyl-l-Tryptophan PET Maps Brain Serotonin Synthesis and Kynurenine Pathway Metabolism

3. Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas

4. In vivo metabolism of tryptophan in meningiomas is mediated by indoleamine 2,3-dioxygenase 1

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