Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

Author:

Patnaik Debasis12ORCID,Pao Ping-Chieh3,Zhao Wen-Ning12ORCID,Silva M. Catarina12,Hylton Norma K.12,Chindavong Peter S.12,Pan Ling3,Tsai Li-Huei3,Haggarty Stephen J.12ORCID

Affiliation:

1. Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, United States

2. Departments of Psychiatry & Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, United States

3. Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Funder

National Institute of Neurological Disorders and Stroke

Alzheimer's Association

Massachusetts General Hospital

National Institute on Aging

Glenn Foundation for Medical Research

Rainwater Charitable Foundation

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Reference49 articles.

1. Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

2. HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

3. Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

4. Tsai, L.H., Pan, L., Haggarty, S. J., and Patnaik, D. (Jan 1, 2019) Activators of class I histone deacetylases (HDACs) and uses thereof, US Patent 10,167,277.

5. Gazave, J. M., Rancurel, A., and Grenier, G. (March 29, 1977) Certain biphenyl derivatives used to treat disorders caused by increased capillary permeability, US Patent 4,015,017A.

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