In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

Author:

Więckowska Anna1ORCID,Szałaj Natalia1,Góral Izabella1,Bucki Adam1ORCID,Latacz Gniewomir1,Kiec-Kononowicz Katarzyna1,Bautista-Aguilera Òscar. M.2,Romero Alejandro3ORCID,Ramos Eva3ORCID,Egea Javier45,Farré Alíns Victor45,González-Rodríguez Águeda45,López-Muñoz Francisco67,Chioua Mourad8,Marco-Contelles José8

Affiliation:

1. Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Kraków, Poland

2. Department of Organic Chemistry and Inorganic Chemistry, Alcalá University, 28805 Alcalá de Henares, Madrid, Spain

3. Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040 Madrid, Spain

4. Health Research Institute, Clinical Pharmacology Service, University Hospital La Princesa, Autonomous University of Madrid, C/Diego de León 62, 28006 Madrid, Spain

5. Institute Teófilo Hernando for Drug I+D, School of Medicine, Autonomous University of Madrid, 28029 Madrid, Spain

6. Faculty of Health Sciences, University Camilo José Cela, C/Castillo de Alarcón 49, 28692 Villanueva de la Cañada, Madrid, Spain

7. Neuropsychopharmacology Unit, Hospital 12 de Octubre Research Institute (i+12), Avda Córdoba, s/n, 28041 Madrid, Spain

8. Laboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain

Funder

Narodowe Centrum Nauki

Universidad Camilo Jos? Cela

Agencia Estatal de Investigaci?n

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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