First Radiolabeling of a Ganglioside with a Positron Emitting Radionuclide: In Vivo PET Demonstrates Low Exposure of Radiofluorinated GM1 in Non-human Primate Brain-Reference-Cited by-同舟云学术

First Radiolabeling of a Ganglioside with a Positron Emitting Radionuclide: In Vivo PET Demonstrates Low Exposure of Radiofluorinated GM1 in Non-human Primate Brain

Published:2020-04-23 Issue:9 Volume:11 Page:1245-1249
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Revunov Evgeny¹,Johnström Peter¹²,Arakawa Ryosuke¹,Malmquist Jonas¹,Jucaite Aurelija¹²,Defay Tom³,Takano Akihiro¹,Schou Magnus¹²^ORCID

Affiliation:

1. Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 17176 Stockholm, Sweden

2. AstraZeneca, PET Science Centre at Karolinska Institutet, Precision Medicine, Oncology R&D, AstraZeneca, Karolinska Institutet, 17176 Stockholm, Sweden

3. Neuroscience, Biopharmaceuticals R&D, AstraZeneca, Boston, Massachusetts 02139, United States

Funder

Knut och Alice Wallenbergs Stiftelse

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.0c00161

Reference20 articles.

1. Ultrastructural localization of cell membrane GM1 ganglioside by cholera toxin

2. Thematic Review Series: Sphingolipids. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease—a review