Deciphering the T790M/L858R-Selective Inhibition Mechanism of an Allosteric Inhibitor of EGFR: Insights from Molecular Simulations
Author:
Affiliation:
1. College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China
Funder
National Natural Science Foundation of China
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.0c00633
Reference48 articles.
1. Small-cell lung cancer: epidemiology, diagnostics and therapy
2. EGFR TKI as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer
3. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
4. Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers
Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Artificial Intelligence in Drug Discovery: A Bibliometric Analysis and Literature Review;Mini-Reviews in Medicinal Chemistry;2024-08
2. Structural Insights into the Binding Mode of a BLU-945 Analog with Wild-Type and Mutant EGFRs;Journal of Computational Biophysics and Chemistry;2024-03-16
3. Unraveling the atomic mechanisms underlying glyphosate insensitivity in EPSPS: implications of distal mutations;Journal of Biomolecular Structure and Dynamics;2024-02-24
4. Allosteric inhibition of myosin by phenamacril: a synergistic mechanism revealed by computational and experimental approaches;Pest Management Science;2023-08-21
5. Structure-based virtual screening and molecular dynamics simulations for detecting novel candidates for allosteric inhibition of EGFRT790M;Journal of Biomolecular Structure and Dynamics;2023-04-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3