Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor-Reference-Cited by-同舟云学术

Subtle Structural Modification of a Synthetic Cannabinoid Receptor Agonist Drastically Increases its Efficacy at the CB1 Receptor

Published:2023-10-17 Issue:21 Volume:14 Page:3928-3940
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Yano Hideaki¹^ORCID,Chitsazi Rezvan²,Lucaj Christopher¹,Tran Phuong²,Hoffman Alexander F.³,Baumann Michael H.⁴^ORCID,Lupica Carl R.³,Shi Lei²^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Bouvé College of Health Sciences, Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States

2. Computational Chemistry and Molecular Biophysics Section, National Institutes of Health, Baltimore, Maryland 21224, United States

3. Electrophysiology Research Section, National Institutes of Health, Baltimore, Maryland 21224, United States

4. Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, United States

Funder

Brain and Behavior Research Foundation

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00530

Reference58 articles.

1. Design, Synthesis and Pharmacology of Cannabimimetic Indoles

2. Identification of 5-Fluoro ADB in Human Whole Blood in Four Death Cases

3. “Zombie” Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York

4. Diagnosing intake and rationalizing toxicities associated with 5F-MDMB-PINACA and 4F-MDMB-BINACA abuse

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