Selective Potentiation of the (α4)<sub>3</sub>(β2)<sub>2</sub> Nicotinic Acetylcholine Receptor Response by NS9283 Analogues-Reference-Cited by-同舟云学术

Selective Potentiation of the (α4)₃(β2)₂ Nicotinic Acetylcholine Receptor Response by NS9283 Analogues

Published:2024-03-21 Issue:7 Volume:15 Page:1501-1514
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Appiani Rebecca¹,Viscarra Franco²³,Biggin Philip C.³^ORCID,Bermudez Isabel²,Giraudo Alessandro¹^ORCID,Pallavicini Marco¹^ORCID,Bolchi Cristiano¹^ORCID

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Mangiagalli 25, Milano I-20133, Italy

2. Department of Biological and Medical Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom

3. Structural Bioinformatics and Computational Biochemistry Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom

Funder

Universit? degli Studi di Milano

Oxford Brookes University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00797

Reference47 articles.

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2. Advances in small molecule selective ligands for heteromeric nicotinic acetylcholine receptors

3. Determinants for α4β2 vs. α3β4 Subtype Selectivity of Pyrrolidine-Based nAChRs Ligands: A Computational Perspective with Focus on Recent cryo-EM Receptor Structures

4. Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype

5. From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at α4β2 nicotinic acetylcholine receptor

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