Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation

Author:

Ramirez Eduardo1ORCID,Ganegamage Susantha K.1,Min Sehong2ORCID,Patel Henika3,Ogunware Adedayo4,Plascencia-Villa Germán4,Alnakhala Heba5,Shimanaka Kazuma5ORCID,Tripathi Arati5,Wang Kuang-Wei6,Zhu Xiongwei7,Rochet Jean-Christophe2ORCID,Kuo Min-Hao6,Counts Scott E.8,Perry George4ORCID,Dettmer Ulf5,Lasagna-Reeves Cristian A.3,Fortin Jessica S.1ORCID

Affiliation:

1. Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States

3. Department of Anatomy Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States

4. Department of Neuroscience, Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas 78249, United States

5. Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, United States

6. Department of Biochemistry and Molecular Biology, College of Natural Science, Michigan State University, East Lansing, Michigan 48824, United States

7. Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, United States

8. Department of Translational Neuroscience, College of Human Medicine, Michigan State University, Grand Rapids, Michigan 49503, United States

Funder

National Institute of Neurological Disorders and Stroke

Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation

Alzheimer Society

Edward Lowe Foundation

U.S. Department of Defense

National Institute on Aging

Pharmaceutical Research and Manufacturers of America Foundation

Branfman Family Foundation

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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