Still in Search for an EAAT Activator: GT949 Does Not Activate EAAT2, nor EAAT3 in Impedance and Radioligand Uptake Assays

Author:

van Veggel Lieve123,Mocking Tamara A.M.4,Sijben Hubert J.4,Liu Rongfang4,Gorostiola González Marina4,Dilweg Majlen A.4,Royakkers Jeroen5ORCID,Li Anna6,Kumar Vijay6,Dong Yin Yao7,Bullock Alex6ORCID,Sauer David B.6,Diliën Hanne5,van Westen Gerard J.P.4ORCID,Schreiber Rudy8,Heitman Laura H.49,Vanmierlo Tim123ORCID

Affiliation:

1. Department of Neuroscience, BIOMED Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, 3590 Hasselt, Belgium

2. Department of Psychiatry and Neuropsychology, Division of Translational Neuroscience, European Graduate School of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, 6200 Maastricht, The Netherlands

3. University MS Center (UMSC), 3900 Hasselt-Pelt, Belgium

4. Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 Leiden, The Netherlands

5. Sensor Engineering Department, Faculty of Science and Engineering, Maastricht University, 6200 Maastricht, The Netherlands

6. Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, OX3 7BN Oxford, U.K.

7. Nuffield Department of Clinical Neurosciences, Weatherall Institute of Molecular Medicine, University of Oxford, OX3 7BN Oxford, U.K.

8. Section of Psychopharmacology, Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, 6200 Maastricht, The Netherlands

9. Oncode Institute, Einsteinweg 55, 2333 Leiden, The Netherlands

Funder

Innovative Medicines Initiative

Fonds Wetenschappelijk Onderzoek

Horizon 2020 Framework Programme

European Federation of Pharmaceutical Industries and Associations

Fondation Charcot

Publisher

American Chemical Society (ACS)

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