Synthesis and Pharmacological Evaluation of M4 Muscarinic Receptor Positive Allosteric Modulators Derived from VU10004
Author:
Affiliation:
1. Medicinal Chemistry and ‡Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381-399 Royal Parade, Parkville VIC 3052, Australia
Funder
National Health and Medical Research Council
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5b00035
Reference17 articles.
1. Xanomeline: A selective muscarinic agonist for the treatment of Alzheimer's disease
2. Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia
3. Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery
4. Allosteric modulators of ligand binding to muscarinic acetylcholine receptors
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