Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models
Author:
Affiliation:
1. Northwestern University, Chicago, Illinois 60611, United States
2. Columbia University, New York, New York 10032, United States
3. University of Kentucky, Lexington, Kentucky 40536, United States
Funder
National Institute of Neurological Disorders and Stroke
Alzheimer Drug Discovery Foundation
National Institute on Aging
Edward N. and Della L. Thome Memorial Foundation
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5b00002
Reference34 articles.
1. U.S. Food and Drug Administration (2001) Novartis, NDA 021335.
2. Advances in kinase targeting: current clinical use and clinical trials
3. Small molecule kinase inhibitors approved by the FDA from 2000 to 2011: a systematic review of preclinical ADME data
4. A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets
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