An Early Folding Contact between Phe19 and Leu34 is Critical for Amyloid-β Oligomer Toxicity
Author:
Affiliation:
1. Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India
2. Institute of Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany
Funder
Department of Biotechnology , Ministry of Science and Technology
Deutsche Forschungsgemeinschaft
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5b00074
Reference48 articles.
1. Protein Misfolding, Functional Amyloid, and Human Disease
2. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
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5. 3D structure of Alzheimer's amyloid- (1-42) fibrils
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