Synthesis and Structure–Activity Relationships of Tool Compounds Based on WAY163909, a 5-HT2C Receptor Agonist
Author:
Affiliation:
1. Department of Chemistry, University of Houston, Houston, Texas 77204, United States
Funder
National Institute on Drug Abuse
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00439
Reference33 articles.
1. Synergism Between a Serotonin 5-HT2A Receptor (5-HT2AR) Antagonist and 5-HT2CR Agonist Suggests New Pharmacotherapeutics for Cocaine Addiction
2. Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction
3. Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers
4. 5-Hydroxytryptamine 5HT2C Receptors Form a Protein Complex with N-Methyl-d-aspartate GluN2A Subunits and Activate Phosphorylation of Src Protein to Modulate Motoneuronal Depolarization
5. Serotonin-2A homodimers are needed for signalling via both phospholipase A 2 and phospholipase C in transfected CHO cells
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1. Synthesis of WAY-163909; a selective 5-HT2CR agonist;Tetrahedron Letters;2022-10
2. Suppression of cocaine relapse-like behaviors upon pimavanserin and lorcaserin co-administration;Neuropharmacology;2020-05
3. Serotonin neurobiology in cocaine use disorder;Handbook of Behavioral Neuroscience;2020
4. In Vivo and In Vitro Analyses of Novel Peptidomimetic Disruptors for the Serotonin 5-HT2C Receptor Interaction With Phosphatase and Tensin Homolog;Frontiers in Pharmacology;2019-08-23
5. Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT 2A receptor (5-HT 2A R) antagonist M100907;Bioorganic & Medicinal Chemistry Letters;2018-05
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