Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression-Reference-Cited by-同舟云学术

Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression

Published:2016-10-18 Issue:12 Volume:7 Page:1635-1640
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Degnan Andrew P.¹,Tora George O.¹,Huang Hong¹,Conlon David A.²,Davis Carl D.¹,Hanumegowda Umesh M.¹,Hou Xiaoping³,Hsiao Yi²,Hu Joanna¹,Krause Rudolph¹,Li Yu-Wen¹,Newton Amy E.¹,Pieschl Rick L.¹,Raybon Joseph¹,Rosner Thorsten²,Sun Jung-Hui³,Taber Matthew T.¹,Taylor Sarah J.¹,Wong Michael K.³,Zhang Huiping³,Lodge Nicholas J.¹,Bronson Joanne J.¹,Macor John E.¹,Gillman Kevin W.¹

Affiliation:

1. Research and Development, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, United States

2. Chemical Development, Bristol-Myers Squibb Company, New Brunswick, New Jersey 08903, United States

3. Department of Chemical Synthesis, Bristol-Myers Squibb Company, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00337

Reference37 articles.

1. The Biochemistry of Affective Disorders