Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy-Reference-Cited by-同舟云学术

Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy

Published:2018-06-14 Issue:11 Volume:9 Page:2542-2547
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Cairns Andrew G.¹,Vazquez-Romero Ana²,Mahdi Moein Mohammad²,Ådén Jörgen¹,Elmore Charles S.³,Takano Akihiro²,Arakawa Ryosuke²,Varrone Andrea²,Almqvist Fredrik¹,Schou Magnus²⁴^ORCID

Affiliation:

1. Department of Chemistry, Umeå University, 901 87 Umeå, Sweden

2. Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76 Stockholm, Sweden

3. Isotope Chemistry, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

4. PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, S-171 76 Stockholm, Sweden

Funder

AstraZeneca

Vetenskapsr?det

G?ran Gustafssons Stiftelse f?r Naturvetenskaplig och Medicinsk Forskning

Kempestiftelserna

VINNOVA

Michael J. Fox Foundation for Parkinson's Research

Stiftelsen f?r?Strategisk Forskning

Publisher

American Chemical Society (ACS)