Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes-Reference-Cited by-同舟云学术

Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes

Published:2018-05-02 Issue:7 Volume:9 Page:1702-1713
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Kamp Frits¹,Scheidt Holger A.²,Winkler Edith¹,Basset Gabriele¹,Heinel Hannes²,Hutchison James M.³,LaPointe Loren M.³,Sanders Charles R.³^ORCID,Steiner Harald¹⁴,Huster Daniel²^ORCID

Affiliation:

1. Biomedical Center - BMC, Metabolic Biochemistry, Ludwig-Maximilians University, Munich 80539, Germany

2. Institute for Medical Physics and Biophysics, Leipzig University, Härtelstr. 16-18, D-04107 Leipzig, Germany

3. Department of Biochemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37240, United States

4. German Center for Neurodegenerative Diseases (DZNE)−Munich, Feodor-Lynen-Str. 17, D-81377 Munich, Germany

Funder

Deutsche Forschungsgemeinschaft

Stiftung VERUM

National Institute on Aging

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.8b00068

Reference84 articles.

1. Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases

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