Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood

Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood–Brain Barrier

Published:2017-07-10 Issue:9 Volume:8 Page:1925-1936
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Raaphorst Renske M.¹^ORCID,Luurtsema Gert²,Schuit Robert C.¹,Kooijman Esther J. M.¹,Elsinga Philip H.²,Lammertsma Adriaan A.¹,Windhorst Albert D.¹

Affiliation:

1. Department of Radiology & Nuclear Medicine, VU University Medical Center, 1081 HV Amsterdam, The Netherlands

2. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9712 CP Groningen, The Netherlands

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acschemneuro.7b00086

Reference36 articles.

1. The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

2. Blood-Brain Barrier ABC-transporter P-glycoprotein in Alzheimer's Disease: Still a Suspect?

3. Role of CNS efflux drug transporters in antiepileptic drug delivery: Overcoming CNS efflux drug transport

4. Radiopharmaceuticals for assessing ABC transporters at the blood-brain barrier

5. (R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation

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