Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease

Author:

Gandini Annachiara12ORCID,Gonçalves Ana Elisa13,Strocchi Silvia1,Albertini Claudia1,Janočková Jana4,Tramarin Anna1,Grifoni Daniela15,Poeta Eleonora1,Soukup Ondrej4ORCID,Muñoz-Torrero Diego6ORCID,Monti Barbara3ORCID,Sabaté Raimon7ORCID,Bartolini Manuela1ORCID,Legname Giuseppe2ORCID,Bolognesi Maria Laura1ORCID

Affiliation:

1. Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, I-40126Bologna, Italy

2. Department of Neuroscience, Laboratory of Prion Biology, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, I-34136Trieste, Italy

3. Pharmaceutical Sciences Postgraduate Program, Center of Health Sciences, Universidade do Vale do Itajaí, Rua Uruguai 458, 88302-202Itajaí, Santa Catarina, Brazil

4. Biomedical Research Center, University Hospital Hradec Kralove, 500 00Hradec Kralove, Czech Republic

5. Department of Life, Health and Environmental Sciences, University of L’Aquila, Via Vetoio, Coppito II, 67100L’Aquila, Italy

6. Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona (UB), Av. Joan XXIII 27-31, E-08028Barcelona, Spain

7. Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Av Joan XXIII 27-31, E-08028Barcelona, Spain

Funder

Ministerio de Ciencia e Innovaci?n

European Regional Development Fund

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

Ministerio de Econom?a y Competitividad

Universit? di Bologna

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior

Ministero dell'Istruzione, dell'Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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