Phosphorylation of Tau R2 Repeat Destabilizes Its Binding to Microtubules: A Molecular Dynamics Simulation Study-Reference-Cited by-同舟云学术

Phosphorylation of Tau R2 Repeat Destabilizes Its Binding to Microtubules: A Molecular Dynamics Simulation Study

Published:2023-01-20 Issue:3 Volume:14 Page:458-467
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Man Viet Hoang¹^ORCID,He Xibing¹^ORCID,Gao Jie²,Wang Junmei¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania15261, United States

2. Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, Ohio43210, United States

Funder

Ohio State University

National Institute on Aging

National Institute of General Medical Sciences

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.2c00611

Reference57 articles.

1. Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

2. Tau protein binds to microtubules through a flexible array of distributed weak sites.

3. Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau

4. Tau pathology and neurodegeneration

5. Tau in physiology and pathology

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