Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold-Reference-Cited by-同舟云学术

Characterization of Pyrrolidinyl-hexahydro-pyranopiperazines as a Novel Kappa Opioid Receptor Agonist Scaffold

Published:2022-06-23 Issue:13 Volume:13 Page:1849-1856
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Reed Brian¹^ORCID,Miller Michael²,Michino Mayako²,Butelman Eduardo R.³,Ben-Ezra Ariel³,Pikus Philip³,Morochnik Michelle³,Kim Yuli³,Ripka Amy⁴,Vacca Joseph⁵,Kreek Mary Jeanne³

Affiliation:

1. Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10065, United States

2. Tri-Institutional Therapeutics Discovery Institute, 413 E. 69th Street, New York, New York 10021, United States

3. Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10065, United States

4. Lucy Therapeutics, 501 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

5. J. Vacca Consulting LLC, Telford, Pennsylvania 18969, United States

Funder

Takeda Pharmaceutical Company

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Tri-Institutional Therapeutics Discovery Institute

Robertson Therapeutic Development Fund

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.2c00258

Reference17 articles.

1. β-Arrestin-biased ligands at seven-transmembrane receptors

2. Combination of cyclohexane and piperazine based κ-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines

3. Synthesis and Pharmacological Evaluation of 5-Pyrrolidinylquinoxalines as a Novel Class of Peripherally Restricted κ-Opioid Receptor Agonists

4. Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses

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