Design, Synthesis, and Pharmacological Evaluation of <i>N</i>-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer’s Disease-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer’s Disease

Published:2022-07-07 Issue:14 Volume:13 Page:2122-2139
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Kumar Bhupinder¹²^ORCID,Dwivedi Ashish Ranjan¹,Arora Tania³,Raj Khadga⁴,Prashar Vikash³,Kumar Vijay⁵^ORCID,Singh Shamsher⁴,Prakash Jyoti³,Kumar Vinod⁵^ORCID

Affiliation:

1. Laboratory of Organic and Medicinal Chemistry, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab 151401, India

2. Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, G.T Road, Moga, Punjab 142001, India

3. Department of Zoology, School of Basic Sciences, Central University of Punjab, Bathinda, Punjab 151401, India

4. Department of Pharmacology, ISF College of Pharmacy, Ghal Kalan, G.T Road, Moga, Punjab 142001, India

5. Laboratory of Organic and Medicinal Chemistry, Department of Chemistry, Central University of Punjab, Bathinda, Punjab 151401, India

Funder

Council of Scientific and Industrial Research

University Grants Commission

Science and Engineering Research Board

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.2c00132

Reference61 articles.

1. The β-Amyloid Hypothesis in Alzheimer's Disease: Seeing Is Believing

2. Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease

3. The role of acetylcholine in learning and memory

4. Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

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