Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure–Activity Relationship Study on Nalfurafine Analogues-Reference-Cited by-同舟云学术

Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure–Activity Relationship Study on Nalfurafine Analogues

Published:2022-11-30 Issue:24 Volume:13 Page:3608-3628
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Li Mengchu¹,Stevens David L.²,Arriaga Michelle²,Townsend E. Andrew²,Mendez Rolando E.²,Blajkevch Nadejda A.²,Selley Dana E.²,Banks Matthew L.²^ORCID,Negus S. Stevens²,Dewey William L.²,Zhang Yan¹³^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia23298, United States

2. Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia23298, United States

3. Institute for Drug and Alcohol Studies, Virginia Commonwealth University, 203 East Cary Street, Richmond, Virginia23298, United States

Funder

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.2c00526

Reference91 articles.

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2. A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists

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4. Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling

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