Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization

Author:

Bondarenko Vasyl1,Chen Qiang1,Singewald Kevin2,Haloi Nandan34,Tillman Tommy S.1,Howard Rebecca J.34,Lindahl Erik34,Xu Yan1567,Tang Pei158ORCID

Affiliation:

1. Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

2. Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

3. Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, PO Box 1031, SE-17121 Solna, Sweden

4. Department of Applied Physics, Swedish e-Science Research Center, KTH Royal Institute of Technology, PO Box 1031, SE-17121 Solna, Sweden

5. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

6. Department of Structural Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

7. Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

8. Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States

Funder

Vetenskapsr?det

National Institute on Drug Abuse

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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