Enhanced Degradation of Mutant <i>C9ORF72</i>-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection-Reference-Cited by-同舟云学术

Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection

Published:2023-04-04 Issue: Volume: Page:
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Vanecek Allison S.¹,Mojsilovic-Petrovic Jelena²,Kalb Robert G.²,Tepe Jetze J.¹^ORCID

Affiliation:

1. Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States

2. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States

Funder

U.S. Public Health Service

Les Turner ALS Foundation

National Institute on Aging

National Public Health Grand Research Foundation

U.S. Army

Heather Koster Family Charitable Fund

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.2c00732

Reference64 articles.

1. The molecular basis of the frontotemporal lobar degeneration–amyotrophic lateral sclerosis spectrum

2. Amyotrophic Lateral Sclerosis

3. Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

4. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

5. Familial versus sporadic amyotrophic lateral sclerosis--a false dichotomy?

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