Structure−Activity Relationship Study of Prion Inhibition by 2-Aminopyridine-3,5-dicarbonitrile-Based Compounds: Parallel Synthesis, Bioactivity, and in Vitro Pharmacokinetics-Reference-Cited by-同舟云学术

Structure−Activity Relationship Study of Prion Inhibition by 2-Aminopyridine-3,5-dicarbonitrile-Based Compounds: Parallel Synthesis, Bioactivity, and in Vitro Pharmacokinetics

Published:2006-12-13 Issue:1 Volume:50 Page:65-73
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

May Barnaby C. H.¹,Zorn Julie A.¹,Witkop Juanita¹,Sherrill John¹,Wallace Andrew C.¹,Legname Giuseppe¹,Prusiner Stanley B.¹,Cohen Fred E.¹

Affiliation:

1. Institute for Neurodegenerative Diseases and Departments of Neurology, Cellular and Molecular Pharmacology, and Biochemistry and Biophysics, University of CaliforniaSan Francisco, San Francisco, California 94158

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061045z

Reference35 articles.

1. Nobel Lecture: Prions

2. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

3. Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation

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